What Causes Some People to Feel Depressed After Ingesting MDMA?

The profound effects of ecstasy on the brain occur when you take the “love drug.” MDMA, ecstasy, or molly has been known to stimulate the activity of a minimum of three neurotransmitters. Neurotransmitters work to transport messages through brain cells that help you perform functions.

By increasing the activity of neurotransmitters, ecstasy makes you feel euphoric and full of energy. The three neurotransmitters known to be affected by MDMA are serotonin, dopamine, and norepinephrine. Ecstasy works like amphetamines, so ecstasy’s effects on the brain stimulate brain activity.

Neurotransmitters are stored inside the brain and are released when ecstasy is consumed. The effects of ecstasy on the brain result in a massive release of serotonin, while dopamine and norepinephrine are released in somewhat lesser quantities.

Serotonin, The Most Significant Neurotransmitter

Among these three neurotransmitters, serotonin is the most significant. Most of the studies based on the effects of molly on the brain focus on the impact of serotonin release. Serotonin is important because it directs essential body functions such as:

  • Emotion
  • Appetite
  • Sleep
  • Pain
  • Mood

An increase in serotonin activity inside the body distorts standard behavior patterns. The brain needs a large amount of serotonin to function correctly. When serotonin is released, the brain loses one of its crucial neurotransmitters.

MDMA Use Associated With Depression

Many people report feeling depressed after coming down from MDMA. This depression is most often mild and lasts for a day or two.

However, some regular users that take higher doses or use it more frequently report feeling depressed for more extended periods after coming down from MDMA.

Most people, however, do not experience any depression while ingesting MDMA. So what is all the fuss about?

What Causes Some Users to Feel Depressed After Ingesting MDMA?

The Depletion of Serotonin

MDMA releases large amounts of serotonin into the brain. The release of serotonin causes people to experience an elevation of mood, feelings of empathy, and emotional closeness with those around them.

Escasty depletes the brain by releasing large amounts of serotonin, which takes the brain time to replenish the serotonin that was released.

So how long does it take for the serotonin levels to be fully restored after someone ingests molly?

It depends on your general health, the amount you took, your genetic makeup, diet, and other random factors.

So there is absolutely no way to tell; however, based on animal studies, scientists conclude that it could take 48 hours to an entire week.

So the mild depression some people experience could be due to the depletion of serotonin.

Too Much Serotonin in The Brain

The release of serotonin also causes the receptors to turn themselves off for a while. The brain tries to achieve balance through the up and downregulation of receptors. These receptors work in conjunction with serotonin and the regulation of mood.

The brain will maintain a balanced mood by responding to the amount of serotonin by turning itself on and off. Many of those receptors will turn off when the brain is flooded with serotonin from ingesting ecstasy.

The majority of receptors will turn on again as soon as the excess amount of serotonin is metabolized. Nevertheless, some receptors may stay off longer, perhaps for days, weeks, or months.

So the depression some users feel may result from serotonin receptors turning off for too long. How often this happens may essentially be due to a genetic factor unique to each individual.

Some people may be genetically predisposed to experience depression after ingesting MDMA.

Preexisting Depression

Some individuals who were previously depressed before ingesting molly might become depressed after consuming molly. Depression is a common mental illness that is usually untreated and undiagnosed. This is true for many teenagers and young adults who experience mild to moderate depression.

Many MDMA users may try to self-medicate their depression by ingesting MDMA. Ecstasy has been proven to be effective in treating patients with severe depression. However, it is not safe to self-medicate yourself without a medical professional.

Are There Ways to Reduce The Risk of Depression While Ingesting MDMA?

Absolutely. Below are a few suggestions that can make a difference.


Frequent use of MDMA increases the likelihood of individuals experiencing depression.

Moreover, you should take the recommended dose according to your body weight. You should also wait a couple of months before you ingest MDMA again.

Eat Well

Your body produces serotonin by combining various amino acids. Maintaining a well-balanced diet that includes enough protein and proper vitamins and minerals will help you stay healthy and avoid serotonin depletion.


Your brain’s restorative processes mainly take place while you sleep. Not sleeping well may significantly lengthen the time your brain takes to replenish serotonin.

Take Lower Doses

Do not take “booster doses” or take more when you come down. When you come down from MDMA, your brain has already depleted a lot of serotonin. So taking booster doses will lengthen the time your brain takes to replenish the lost serotonin.

Advantages of 5HTP in Ecstasy Comedown

Many molly users report that 5-Hydroxy-Tryptophan (5-htp) helps reduce depression caused by ingesting MDMA. The amino acid supplement (5-htp) is a direct precursor to serotonin in the brain.

5-Hydroxy-Tryptophan is found in most health food stores as an herbal supplement and is extracted from Griffonia seeds.

Clinical studies have shown that 5-htp has successfully relieved symptoms of depression in many people. The supplement relieves these symptoms by increasing the amount of 5-htp in the brain, allowing the brain to produce serotonin.

Supplementing with 5-htp may lessen post-E depression by quickly restoring your body’s serotonin levels.

The advantages of taking 5-htp are:

  • Improving your mood
  • Appetite
  • Sexual function
  • Body temperature
  • Reduce post-E depression
  • It helps restore your body’s serotonin levels

Clinicians widely prescribe 5-htp to help prevent depression, anxiety, and sleep disorders. Furthermore, 5-htp can also be used to treat drug addiction and rehabilitation, especially for ecstasy users.


Magic Mushrooms Can Heal Depression and Anxiety

The hallucinogen in “magic mushrooms” can rapidly and successfully help deal with anxiety and depression in cancer clients, a result that might last for months, 2 little research studies show.

It worked for Dinah Bazer, who sustained a terrifying hallucination that rid her of the fear that her ovarian cancer would return. And for Estalyn Walcoff, who says the drug experience led her to begin a reassuring spiritual journey.

The work released Thursday is preliminary and specialists state more definitive research should be done on the effects of the substance, called psilocybin (sih-loh-SY’- bihn).

Magic Mushrooms in The Treatment of Depression and Anxiety

But the record so far reveals “very impressive outcomes,” said Dr. Craig Blinderman, who directs the adult palliative care service at the Columbia University Medical Center/New York-Presbyterian Healthcare Facility. He didn’t however participate in the work.

Psilocybin, likewise called shrooms, purple passion, and little smoke comes from certain kinds of mushrooms.

It is unlawful in the U.S., and if the federal government approves the treatment, it would be administered in clinics by specifically trained personnel, specialists state.

Nobody must try it on their own, which would be dangerous, said the leaders of the two research studies, Dr. Stephen Ross of New York University and Roland Griffiths of Johns Hopkins University in Baltimore.

Hallucinogens have looked promising in the past for dealing with distress in cancer patients. However, studies of medical use of psychedelics stopped in the early 1970s after a regulative crackdown on the drugs, following their prevalent recreational usage. It has gradually resumed in the last few years.

The Research Study

Griffiths said it’s not clear whether psilocybin would work outside of cancer clients, although he thinks it may work in individuals dealing with other terminal conditions.

Plans are also underway to study it in anxiety that withstands standard treatment, he stated.

The brand-new research studies, released in the Journal of Psychotherapy, are small. The NYU task, which also consisted of psychiatric therapy, covered simply 29 patients. The Hopkins study had 51.

Bazer, who lives in New York City, was diagnosed with ovarian cancer in 2010 when she was 63. Treatment succeeded, however then she ended up being distressed about it returning.

I just started to be filled with a dreadful fear, she said in an interview. You’re awaiting the other shoe to drop…(The stress and anxiety) was destroying my life.

She swallowed a capsule of psilocybin in 2012 in the company of two staff members trained to guide her through the number of hours that the drug would impact her brain. As she listened to music through headphones, her eyes were covered with a sleeping mask, the drug went to work.

Suddenly I remained in a dark, terrifying place, lost in space, lost in time, she remembered. I had no bearings and I was really, truly frightened.

Then she saw her dread of a cancer recurrence as a black mass in her abdomen, and she yelled at it to leave.

As soon as that occurred, the worry was gone, she said. I was simply drifting in the music…like being carried in a river.

Then she felt a deep love for her family and friends and sensed their love for her.

It seemed like I was bathed in God’s love…I’m still an atheist, by the way, however that really seemed to be the only way to explain it.

Researchers said such magical experiences appeared to contribute to the drug’s restorative result.

Walcoff, 69, a psychotherapist in Rochester, New York, likewise entered the NYU study because of her stress and anxiety over a cancer reoccurrence, in her case, lymphoma. (Many individuals had active cancer.).

Psilocybin opened me up to pursue as pursue meditation and spiritual browsing, Walcoff stated, and as a result of that I have ended up being reassured and persuaded that phase of my life is over and it’s not going to return.

The majority of financing for the studies originated from the Heffter Research Institute, a not-for-profit company that supports research studies of psilocybin and other hallucinogens.

Magic Mushrooms Showed Promising Results

In both studies, psilocybin treatment had more of an impact on anxiety and depression than a placebo did.

For example, day by day after treatment, about 80 percent of the treated NYU patients no longer qualified as clinically anxious or depressed by standard measures.

That compares to about 30 percent for the placebo group. That’s an incredibly fast reaction, professionals stated, and it sustained for the seven weeks of the comparison.

The research studies took different methods for developing a placebo. At NYU, patients were offered niacin, which simulates some effects of psilocybin. At Hopkins, the placebo was an extremely low dosage of psilocybin itself.

Researchers in both research studies eventually gave complete psilocybin treatment to the placebo groups and followed all the patients for about six months.

The beneficial effects appeared to continue over that period. But the evidence for that is not as strong as for the much shorter term, because there was no longer any placebo comparison group.

No serious negative effects occurred from the treatment.

Dr. William Breitbart, chief of the psychiatry service at Memorial Sloan-Kettering Cancer Center in New York, who didn’t participate in the research studies, said they were improvements over prior research study on the topic.

However there were still sufficient drawbacks to make him cautious about drawing conclusions, he stated.

In any case, Bazer and Walcoff state the treatment impacted more than their cancer anxieties.

Walcoff said it has helped her deal with being less judgmental and more self-accepting. Bazer stated it made her a more patient driver and more active socially.

It truly changed everything for me, Bazer stated. And I still do not have anxiety about the cancer coming back.


The Importance of Testing LSD

What is Acid?

Acid, the more quotidian name of LSD (lysergic acid diethylamide) is a psychedelic that was produced in 1938 by scientist Albert Hoffman, who was working for the Swiss business Sandoz Pharmaceuticals.

He had actually intended for it to be used as a respiratory and circulatory stimulant, without having realized its psychoactive properties.

It took him an additional 6 years to uncover and appreciate its psychedelic qualities: First, he accidentally ingested a little bit of LSD on April 16, 1943, and after three days he purposely took another hit on April 19 and rode his bicycle home, high on acid. This day is now recognized as the holiday Bicycle Day.

While LSD was used as a “truth serum” by the CIA, it was additionally made mainstream most particularly during the 1960s by nonconformity symbols Timothy Leary and Ram Dass (otherwise known as Richard Alpert), both psychology professors at Harvard at that point, and early psychonauts.

Effects of LSD

LSD binds to various 5-Hydroxytryptamine (5-HT) receptors in the mind, which causes an abundance of serotonin in the synaptic cleft between neurons.

LSD can alter perception, mood, and cognitive processes by acting upon the serotonergic framework.

It similarly follows up on the dopaminergic framework, which impacts processes like learning, reward systems, and motivation.

The increased levels of dopamine and serotonin on LSD can make you feel energetic and give you an extroverted experience.

Acid can help the creative mind and faculties, invigorate thoughts, cause sensations of euphoria, universal connection, or on the opposite side anxiety or paranoia, and can produce hallucinations.

As a conventional psychedelic, LSD in sufficiently high doses may trigger temporary ego dissolution that can prompt mystical experiences and a feeling of transcendence.

Before it was illegal by the Nixon administration under the Controlled Substances Act, LSD was utilized as a powerful apparatus in psychotherapy.

Today, researchers are returning to acid as a tool for addiction treatment, alongside anxiety, depression, and other different conditions.

How Long Does LSD Last?

The impacts of LSD can last somewhere in the range of eight to 12 hours, or in some cases significantly more.

What Does Acid Look Like?

LSD mostly comes in the form of a fluid, or as a tab (whereupon that fluid has been dispersed with a dropper), torn from a piece of perforated paper.

In other cases, acid may be in the form of tablets, capsules, or gelatin squares.

Testing Acid

The LSD market looks somewhat different from MDMA. Till as of late, LSD counterfeits weren’t considered particularly hazardous.

Anyway, the influx of a class of drugs known as NBOMes around ten years sooner adjusted that. Variations of NBOMe, which addresses N-benzyl methoxy, at the same time thicken the blood and constrict vessels, potentially causing heart attacks, kidney failure, or stroke.

Fentanyl and analogs like carfentanyl moreover appear as counterfeits or adulterants in the LSD market today.

In recent years, the illicit markets have, somewhat, cleaned themselves up (with certain distributors currently refusing to sell fentanyl or fentanyl analogs for instance), an inconceivable determination of pristine, illegal mixtures and illicit compounds struck the market each year.

Other than limitations and growing demand, factors contributing to the illegal market today include the rise of the dark web and the front of protection provided by cryptocurrencies.

At the point when it concerns the expectations of illicit producers and vendors, WIM Scientific Laboratories, gives these people the upside of the uncertainty.

Instead, a few producers and sellers are likely ignorant of the intricate details of new particles or research study synthetic substances which, much of the time, mimic the effects of the better-known drugs, but carry more risks. Some probably won’t have a clue of what they’re selling.

Testing Acid at a Glance

The most recent decade has really seen an extension of drugs sold on blotter paper resembling LSD, however with significant degrees of toxicity.

NBOMes mimic the effects of LSD but extensively carry more risk; the analog known as 25i NBOMe is highly toxic.

Between 2013 and 2016, roughly an individual passed away one month after ingesting an NBOMe sold as LSD; fortunately, the rate has since slowed down.

Carfentanyl, a staggeringly powerful fentanyl analogue, is- – like LSD- – active at the microgram level. Since it’s regularly sold on blotter paper, disarray in the middle of the two drugs can emerge.

The DO series of drugs, including DOB and DOC, are psychedelics, at times sold as LSD, that commonly have longer-lasting effects and are not well documented for safety.

LSD testing kits are simpler than those for MDMA: Ehrlich’s reagent turns purple within the presence of LSD or other related drugs.

Drug Testing and The Law

Law enforcement and harm reduction endeavors have a checkered relationship. For instance, about half of U.S. states have laws criminalizing testing agents and paraphernalia.

Anyway, with regards to testing, these laws are rarely implemented. To our knowledge, no one with WIM Scientific Laboratories- – staff, volunteer, or festival-goer- – has ever been imprisoned for taking an interest in drug testing.

In some cases, WIM Scientific Laboratories works under pardon concurrences with local law enforcement – that bodes well from a delicate perspective, considering the reality that fewer deaths and injuries happen when testing and other harm reduction strategies are at play.

The Psychedelic Renaissance and Drug Testing

There are various factors for the comeback of psychedelics. They’re a productivity hack in small doses and a socially-bolding apparatus created for dancing. They likewise help quench the yearning many of us need to comprehend the self corresponding to the whole – to see past deception and step into another way of being.

In light of psychedelics’ forthcoming remedial uses for PTSD specifically, we believe that the current renaissance is a means of aggregate recuperating from 9/11- – and today, amidst the Covid crisis, we may see much more important relevance for the restorative therapeutic uses of psychedelics.

Notwithstanding, as long as prohibition perseveres through, the counterfeiting issue will remain.

The more compelling the Drug War is at taking action against genuine MDMA and LSD, the more inspiration there’ll be for making and selling counterfeits.


Why an MDMA Drug Testing Kit Could Save Lives

Drug Screening

Drug testing, sometimes called drug monitoring, is an essential damage decrease technique to guarantee that a compound is genuinely what you think it is, and not adulterated by possibly toxic chemicals that might cause an unpleasant or fatal reaction.

The very best aspect of drug checking is that you don’t need a whole chemistry lab to do it!

In fact, you can test your drugs in the privacy of your own home with a drug checking kit such as the ones we like and trust for MDMA or LSD from WIM Scientific Laboratories, Certainly, drug checking is simple, requiring just a couple of reagents (liquid testers) to determine whether your substance is pure, or contains other elements.

What is MDMA (a.k.a. Molly)?

MDMA, also referred to as euphoria, e, x, or molly, first surfaced as a psychotherapeutic aid in the 1970s. Though analogs of the drug had been manufactured earlier, many sources credit chemist Alexander “Sasha” Shulgin for finding the formula, in addition to psychotherapist Leo Zeff for helping bring its psychotherapeutic properties to light.

Because of MDMA’s specific euphoric and compassionate influence on the user, it guaranteed restorative settings for recovery trauma and promoting individual and spiritual growth.

In the 1970s and 1980s, early adopters caught word of the particle’s leisure uses, and by 1985 MDMA– likewise known by its chemical name, methylenedioxymethamphetamine– was noted in the U.S. as a Schedule I drug.

Impacts of MDMA

MDMA triggers your serotonin nerve cells in the brain to launch bigger quantities of serotonin. It likewise causes the release of dopamine neurotransmitters, as well as oxytocin and prolactin hormones.

This impact can lead to feelings of ecstasy, greater desire to interact, reduced worry, increased connection to others, and feelings of love or compassion.

MDMA moreover decreases activity in the amygdala, which is where memories are stored. This impact, coupled with those listed above, is why MDMA has actually been so helpful in dealing with PTSD, which the nonprofit MAPS (Multidisciplinary Association for Psychedelic Research studies) is currently examining.

In fact, MDMA for PTSD has been placed on the FDA fast track to become an approved medication in psychedelic-assisted psychotherapy early this decade. MAPS is presently in the 3rd and last phase of the FDA-approved research study.

On the physical side, MDMA might cause loss of appetite, shivering, sensations of restlessness, or even sensations of heat.

It is essential to note that MDMA ought to not be handled on a routine basis, as for some, there is a comedown, which involves the time it takes for your brain to replenish its serotonin.

How Long Does Molly Last?

The total length of MDMA is about three to six hours, with an initial start of 20 to 90 minutes.

What Does Molly Look Like?

MDMA often comes as a white or light brown crystalline powder, contained in a clear capsule.

Sometimes it might come as light brown rocks. In other cases, particularly if you’re taking ecstasy (which might contain other parts beyond MDMA), it comes as a pressed tablet, which might be a range of colors and include a style.

Why You Should Test Your Molly

Eduard Marquis, a Russian pharmacologist, developed this test in 1896. It was first tested at the University of Dorpat and now is extensively utilized as a fundamental area test. History reveals that drug monitoring has actually been associated with nightlife and music scenes of numerous European nations since the 1990s.

This development of raves and dance-music culture also impacted Australia in the 1970-80s. Throughout this time, “party-drugs” like psychedelic substances became very popular. Drug checking and regent test quickly followed as a damage reduction method.

In the 21st century, an extremely comparable usage is used. The Marquis Reagent test was particularly popular given that it responds with a lot of drugs used in the dance scene.

MDMA restriction has produced the most adulterated market in history.

Over the last few years, numerous drugs have actually been sold as euphoria or molly which contain little to no MDMA.

Of the numerous fake drugs WIM Scientific Laboratories has checked, dangerous cathinone (a.k.a. “bath salts”) and methamphetamines surface area often.

While these MDMA fakes may yield psychedelic results, they won’t likely feel as pleasant or expected as those of MDMA. And, in the wrong dosages, they might also be fatal.

To be ultra-clear: It’s counterfeiting– which results from prohibition, and a without supervision black market– that poses the most significant threat; in the best doses, and with a thoughtful set and setting, taking MDMA (a.k.a. rolling) is an enjoyable, transcendent, and even restorative experience for a lot of people.

Customers of an unadulterated variation of the drug can suffer negative effects and even pass away, if they take too big of a dose, or drink too much or insufficient water during the roll.

However, the dangers grow when those who believe they have actually taken MDMA have in fact taken meth, PMA, cathinone, or something else completely.

Testing is crucial because you can’t reliably identify MDMA by appearance, odor, or taste.

WIM Scientific Laboratories provides testing kits for MDMA, LSD, and a variety of other substances, both online and at festivals. The point of the MDMA testing package is to tell you whether the main ingredient is what you intended to take in.

MDMA testing at a glance:

  • Common MDMA counterfeits: PMA and PMMA (2 compounds producing comparable results to MDMA however with more toxicity), cathinone (aka “bath salts”), and methamphetamine
  • Threats of consuming counterfeits include: hypertension, elevated temperature level, trouble breathing, and death
  • The majority of counterfeits don’t include any MDMA
  • Roughly 80-90 percent of what’s offered today as MDMA is authentic; as just recently as 2015, that figure was closer to 30 percent
  • Fentanyl, the dangerous synthetic opioid, hasn’t surfaced on the MDMA market yet, though some observers think it could quickly
  • Used together, these reagents can reliably identify whether MDMA is the main ingredient in a tablet– though they can’t show absolute pureness
  • Follow all the steps in the kit when testing in the house. Check out the testing set directions in advance and make sure you’re sober when you test.